An immunochemical marker of low density lipoprotein oxidation.
نویسندگان
چکیده
منابع مشابه
Glucose Influence on Copper Ion-Dependent Oxidation of Low Density Lipoprotein
Background: It is well established that oxidative modification of low density lipoprotein (LDL) plays a causal role in human atherogenesis and the risk of atherosclerosis is increased in patients with diabetes mellitus. We examined the in vitro effect of glucose on native and glycated LDL oxidation using copper ion dependent oxidation system. Methods: In this study, LDL was isolated from plasma...
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Oxidation of low density lipoprotein (LDL) has been strongly implicated in the phathogenesis of atherosclerosis. The use of oxidants in dietary food stuff may lead to the production of oxidized LDL and may increase both the development and the progression of atherosclerosis. The present work investigated the effects of some elements including: copper (Cu), iron (Fe), vanadium (V) and titanium (...
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Background: Oxidative modification of low-density lipoprotein (LDL) appears to be an early step in the pathogenesis of atherosclerosis. Meanwhile, myeloperoxidase (MPO)-catalyzed reaction is one of the potent pathway for LDL oxidation in vivo. The aim of this study was to evaluate in vitro antioxidant effects of vitamins C and E on LDL oxidation mediated by MPO. Methods: MPO was isolated from f...
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Copper-oxidized LDL has many of the characteristics of the modified LDL generated in the artery wall during the initial stages of atherosclerosis. It is not, however, a chemically defined species but shows significant variations in both its chemical composition and behaviour in biological systems depending upon the extent to which the peroxidation reaction has occurred (Fig. 1). Taking care to ...
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Antioxidant drugs and the inhibition of low-density lipoprotein oxidation Emma S. R. Green, Chris E. Cooper*, Michael J. Daviest and Catherine Rice-Evans Free Radical Research Group, Division of Biochemistry, UMDS-Guy's Hospital, Thomas's Street, London SE I 9RT, *Division of Biomolecular Sciences, King's College London, Campden Hill Road, London W8 7AH and +Department of Chemistry, University ...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1989
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)38305-x